In routine clinical care settings, 50% of patients with chronic pain do not experience adequate pain relief.1
Therapeutic outcome is currently compromised by high rates of tolerability-related treatment discontinuations.2
Currently, pharmacological treatment of severe chronic pain is often ineffective.2
- Because it is hard to maintain a balance between pain relief (analgesia) and tolerability of the medication.2
- Galvez R. Variable use of opioid pharmacotherapy for chronic non-cancer pain in Europe: causes and consequences. Journal of Pain & Palliative Care Pharmacotherapy, 2009;23(4):346-356.
- Varrassi G et al. Pharmacological treatment of chronic pain – the need for CHANGE. Curr Med Res Opin 2010;26(5):1231-1245.